ZNF319

Across TCGA patient cohorts, ZNF319 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF319-associated genes across cancer lineages are MSH2, Caspase-7-cleavedD198, and 14-3-3_beta. Each is linked with ZNF319 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF319-to-partner and partner-to-ZNF319 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH2 grouped by ZNF319-low versus ZNF319-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF319→partner) and Y-score (partner→ZNF319) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSH2 →	-0.270	-2.674	<.001	.005	3	2
UCEC	Caspase-7-cleavedD198 →	+0.701	+2.222	<.001	.009	3	2
UCEC	14-3-3_beta →	-0.089	-2.088	.011	.016	3	1
UCEC	JNK2 →	+0.229	+3.348	.001	.004	3	1
UCEC	MEK1 →	+0.399	+2.584	.001	.001	3	1
UCEC	MSH6 →	-0.327	-1.700	.004	.040	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

MSH2 by ZNF319 expression — UCEC

Explore this box plot interactively →