ZNF319

Across TCGA pan-cancer cohorts, ZNF319 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of ZNF319’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ZNF319 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ZNF319 is over-expressed in tumor, although a few such as BRCA and UCEC show the opposite, repressed pattern.

HNSC, KIRP, and LIHC are the cancer types where ZNF319 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZNF319 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+1.537	<.001	12	view →
KIRP	All	II,III,IV	+1.102	<.001	11	view →
LIHC	Female	II,III,IV	+0.791	<.001	8	view →
COAD	Female	All	+0.478	<.001	7	view →
BLCA	Female	III,IV	+1.187	.002	6	view →
BRCA	Female	II,III,IV	−0.433	<.001	6	view →
CHOL	All	All	+1.700	<.001	5	view →
KIRC	All	All	+0.329	<.001	5	view →
STAD	Male	II,III,IV	+0.856	.006	4	view →
UCEC	All	All	−0.683	<.001	4	view →
LUAD	All	All	+0.261	.006	3	view →
THCA	All	All	+0.319	.006	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

ZNF319–HNSC

Open the HNSC breakdown →