ZNF317

Across TCGA patient cohorts, ZNF317 mutation is significantly associated with the RNA expression of many other genes, with 6,155 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF317-associated genes across cancer lineages are PRDX3, MIR6754, and OXSM. Each is linked with ZNF317 in more than 3 cancer types. Because this analysis shows association rather than direction, both ZNF317-to-partner and partner-to-ZNF317 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRDX3 grouped by ZNF317-low versus ZNF317-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF317→partner) and Y-score (partner→ZNF317) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PRDX3 →	+0.583	+1.893	<.001	<.001	3	4
BRCA	MIR6754 →	+0.441	+4.883	<.001	.006	3	3
UCEC	OXSM →	+0.378	+3.169	<.001	<.001	3	3
UCEC	C18orf25 →	+0.507	+2.180	<.001	<.001	3	3
UCEC	BUB3 →	+0.697	+3.321	<.001	<.001	3	3
UCEC	USP1 →	+0.773	+2.506	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,155 associations by consensus.

PRDX3 by ZNF317 expression — UCEC

Explore this box plot interactively →