ZNF317

Across TCGA pan-cancer cohorts, ZNF317 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of ZNF317’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ZNF317 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ZNF317 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

HNSC, COAD, and KIRP are the cancer types where ZNF317 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZNF317 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+0.776	<.001	12	view →
COAD	All	III,IV	+0.576	<.001	11	view →
KIRP	All	II,III,IV	+0.512	.005	10	view →
LIHC	Female	II,III,IV	+0.979	<.001	9	view →
STAD	Male	II,III,IV	+0.794	<.001	8	view →
THCA	Male	II,III,IV	−0.513	<.001	8	view →
BLCA	All	All	+0.404	.002	6	view →
CHOL	All	All	+1.970	<.001	5	view →
LUSC	All	All	+0.305	<.001	4	view →
KIRC	All	All	+0.243	<.001	4	view →
ESCA	All	All	+0.591	.023	1	view →
READ	All	All	+0.394	.015	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

ZNF317–HNSC

Open the HNSC breakdown →