ZNF317

Across TCGA patient cohorts, ZNF317 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF317-associated genes across cancer lineages are Caspase-7-cleavedD198, FoxM1, and JNK2. Each is linked with ZNF317 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF317-to-partner and partner-to-ZNF317 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by ZNF317-low versus ZNF317-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF317→partner) and Y-score (partner→ZNF317) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.422	+1.700	.033	.040	3	3
UCEC	FoxM1 →	+0.203	+2.201	.019	<.001	3	2
UCEC	JNK2 →	+0.254	+2.584	<.001	<.001	3	2
UCEC	MEK1 →	+0.383	+2.584	.001	.001	3	2
UCEC	Notch1 →	+0.174	+2.920	<.001	<.001	3	2
UCEC	p62 Lck ligand →	+0.320	+2.201	.003	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

Caspase-7-cleavedD198 by ZNF317 expression — UCEC

Explore this box plot interactively →