ZNF300

Across TCGA patient cohorts, ZNF300 mutation is significantly associated with the RNA expression of many other genes, with 2,328 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF300-associated genes across cancer lineages are MIR623, PRYP5, and RNU7-173P. Each is linked with ZNF300 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF300-to-partner and partner-to-ZNF300 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR623 grouped by ZNF300-low versus ZNF300-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF300→partner) and Y-score (partner→ZNF300) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MIR623 →	+0.733	+3.709	<.001	.007	3	2
BRCA	PRYP5 →	+0.087	+7.473	<.001	.007	3	2
HNSC	RNU7-173P →	+0.534	+3.816	<.001	.004	3	2
CESC	LINC02559 →	+1.058	+4.757	<.001	.004	3	2
CESC	LINC02380 →	+0.176	+4.345	<.001	.002	3	2
UCEC	SLC35C1 →	+0.366	+1.347	.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,328 associations by consensus.

MIR623 by ZNF300 expression — HNSC

Explore this box plot interactively →