ZNF3

Across TCGA cell cohorts, ZNF3 mutation is significantly associated with the RNA expression of many other genes, with 19 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ZNF3-associated genes across cancer lineages are OR14A16, KRTAP4-11, and GML. Each is linked with ZNF3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF3-to-partner and partner-to-ZNF3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR14A16 grouped by ZNF3-low versus ZNF3-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF3→partner) and Y-score (partner→ZNF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	OR14A16 →	+0.016	+5.643	<.001	.002	3	1
BLOOD_Lymphoma	KRTAP4-11 →	+0.038	+5.209	<.001	.005	3	1
BLOOD_Leukemia	GML →	+0.080	+4.152	<.001	.009	3	1
BLOOD_Leukemia	GNGT1 →	+0.050	+4.551	.002	.004	3	1
BLOOD_Leukemia	TACR3 →	+0.038	+5.060	<.001	.001	3	1
BLOOD_Leukemia	NKX2-6 →	+0.489	+5.786	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

OR14A16 by ZNF3 expression — BLOOD_Lymphoma

Explore this box plot interactively →