ZNF283

Across TCGA pan-cancer cohorts, ZNF283 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated ZNF283 data layer compared with 23 for mass-spec protein.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where higher ZNF283 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated ZNF283 expression acts as an unfavorable survival marker, although some lineages such as STAD and UCEC show a favorable association.

OV, CESC, and STAD are the cancer types where ZNF283 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
OV	OS	Median	II,III,IV	0.304	0.691	.030	18	view →
CESC	OS	Median	III,IV	0.068	0.756	<.001	12	view →
STAD	DFS	Median	II,III,IV	1.000	0.377	.040	5	view →
UCEC	DFS	Median	All	0.918	0.620	.034	4	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

ZNF283–OV (OS)

Open the OV breakdown →