ZNF283

Across TCGA pan-cancer cohorts, ZNF283 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of ZNF283’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where ZNF283 RNA is repressed in tumor relative to normal tissue. In most cancer types ZNF283 is over-expressed in tumor, although a few such as THCA and KIRP show the opposite, repressed pattern.

THCA, BLCA, and LIHC are the cancer types where ZNF283 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZNF283 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	All	−0.489	<.001	10	view →
BLCA	All	All	+0.406	.002	9	view →
LIHC	Female	III,IV	+0.480	<.001	8	view →
LUAD	Male	All	+0.573	<.001	7	view →
COAD	All	All	+0.320	<.001	6	view →
CHOL	Female	All	+1.766	<.001	5	view →
LUSC	All	All	+0.241	.005	4	view →
ESCA	Female	All	+0.633	.004	2	view →
STAD	All	II,III,IV	+0.353	.026	2	view →
KIRP	Male	All	−0.299	.015	2	view →
KICH	All	All	−0.293	.045	2	view →
PRAD	All	All	+0.261	.002	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

ZNF283–THCA

Open the THCA breakdown →