ZNF283

Across TCGA patient cohorts, ZNF283 mutation is significantly associated with the RNA expression of many other genes, with 2,505 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF283-associated genes across cancer lineages are SKA1, GHITM, and LSM3. Each is linked with ZNF283 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF283-to-partner and partner-to-ZNF283 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SKA1 grouped by ZNF283-low versus ZNF283-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF283→partner) and Y-score (partner→ZNF283) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SKA1 →	+0.598	+1.949	<.001	.001	3	3
UCEC	GHITM →	+0.430	+2.169	.007	.003	3	3
UCEC	LSM3 →	+0.398	+2.263	.007	<.001	3	3
UCEC	MRM3 →	+0.337	+3.721	.003	<.001	3	3
SKCM	ME2 →	+0.652	+3.198	.007	.009	3	3
SKCM	LINC01815 →	+0.035	+4.049	<.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,505 associations by consensus.

SKA1 by ZNF283 expression — UCEC

Explore this box plot interactively →