ZNF283

Across TCGA patient cohorts, ZNF283 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF283-associated genes across cancer lineages are eEF2, p38-MAPK_pT180_Y182, and PCNA. Each is linked with ZNF283 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF283-to-partner and partner-to-ZNF283 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by ZNF283-low versus ZNF283-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF283→partner) and Y-score (partner→ZNF283) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.275	+2.459	.033	.018	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.422	-2.415	.009	.003	3	2
UCEC	PCNA →	+0.227	+2.321	.003	.001	3	2
UCEC	Src_pY527 →	-0.369	-1.584	.017	.019	3	2
UCEC	ASNS →	+0.474	+2.415	<.001	.003	3	2
UCEC	ATM →	-0.581	-2.321	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

eEF2 by ZNF283 expression — UCEC

Explore this box plot interactively →