ZNF281

Across TCGA patient cohorts, ZNF281 mutation is significantly associated with the RNA expression of many other genes, with 3,660 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF281-associated genes across cancer lineages are TRGJP2, MIR3667, and RNU6-1103P. Each is linked with ZNF281 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF281-to-partner and partner-to-ZNF281 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRGJP2 grouped by ZNF281-low versus ZNF281-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF281→partner) and Y-score (partner→ZNF281) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	TRGJP2 →	+0.714	+2.752	<.001	.002	3	3
SARC	MIR3667 →	+0.871	+5.224	<.001	.006	3	3
BRCA	RNU6-1103P →	+0.179	+8.057	<.001	.005	3	2
UCEC	LINC02084 →	+0.457	+2.061	<.001	<.001	3	2
UCEC	RN7SL248P →	+0.047	+2.722	<.001	.002	3	2
UCEC	UHRF1 →	+0.674	+2.061	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,660 associations by consensus.

TRGJP2 by ZNF281 expression — COAD

Explore this box plot interactively →