ZNF280C

Across TCGA pan-cancer cohorts, ZNF280C Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated ZNF280C data layer compared with 24 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher ZNF280C Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated ZNF280C expression acts as an unfavorable survival marker, although some lineages such as UCEC and READ show a favorable association.

UCEC, LUAD, and SCLC are the cancer types where ZNF280C Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.971	0.613	.003	34	view →
LUAD	DFS	Median	All	0.492	0.793	.016	17	view →
SCLC	OS	Median	All	0.082	0.653	.002	6	view →
READ	DFS	Median	III,IV	1.000	0.304	.040	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

ZNF280C–UCEC (DFS)

Open the UCEC breakdown →