ZNF280C

Across TCGA pan-cancer cohorts, ZNF280C mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated ZNF280C data layer compared with 24 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher ZNF280C mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated ZNF280C expression acts as an unfavorable survival marker, although some lineages such as LUAD and UCEC show a favorable association.

PDAC, LUAD, and UCEC are the cancer types where ZNF280C mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	II,III,IV	0.658	0.786	.003	32	view →
LUAD	DFS	Quartile	III,IV	0.912	0.322	.004	13	view →
UCEC	DFS	Median	All	1.000	0.938	.026	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

ZNF280C–PDAC (DFS)

Open the PDAC breakdown →