ZNF280C

Across TCGA patient cohorts, ZNF280C mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF280C-associated genes across cancer lineages are EGFR_pY1068, ERK2, and MEK1. Each is linked with ZNF280C in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF280C-to-partner and partner-to-ZNF280C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by ZNF280C-low versus ZNF280C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF280C→partner) and Y-score (partner→ZNF280C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.213	-1.222	.008	.035	3	2
UCEC	ERK2 →	+0.168	+1.584	.007	.034	3	2
UCEC	MEK1 →	+0.344	+1.716	.003	.003	3	2
UCEC	PCNA →	+0.193	+2.000	.005	.009	3	2
UCEC	PDCD4 →	-0.401	-1.700	.008	.040	3	2
UCEC	Caspase-7-cleavedD198 →	+0.638	+2.522	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

EGFR_pY1068 by ZNF280C expression — UCEC

Explore this box plot interactively →