ZNF280C

Across TCGA cell cohorts, ZNF280C RNA expression is significantly associated with the go_rna of many other GO terms, with 5,358 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ZNF280C-associated GO terms across cancer lineages are Positive regulation of termination of RNA polymerase II transcription, Positive regulation of termination of DNA-templated transcription, and Regulation of sister chromatid cohesion. Each is linked with ZNF280C in more than 15 cancer types. Because this analysis shows association rather than direction, both ZNF280C-to-partner and partner-to-ZNF280C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of termination of RNA polymerase II transcription grouped by ZNF280C-low versus ZNF280C-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF280C→partner) and Y-score (partner→ZNF280C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Positive regulation of termination of RNA polymerase II transcription →	+0.140	+0.841	<.001	<.001	3	16
OVARY	Positive regulation of termination of DNA-templated transcription →	+0.140	+0.841	<.001	<.001	3	16
OVARY	Regulation of sister chromatid cohesion →	+0.100	+0.921	<.001	<.001	3	16
LUNG_SCLC	Positive regulation of telomerase RNA localization to Cajal body →	+0.110	+0.662	<.001	.001	3	15
LUNG_SCLC	Heterochromatin formation →	+0.070	+0.782	<.001	<.001	3	15
BONE	Negative regulation of gene expression via chromosomal CpG island methylation →	+0.206	+1.276	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,358 associations by consensus.

Positive regulation of termination of RNA polymerase II transcription by ZNF280C expression — OVARY

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