ZNF280B

Across TCGA patient cohorts, ZNF280B mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF280B-associated genes across cancer lineages are eEF2, FoxM1, and p38-MAPK_pT180_Y182. Each is linked with ZNF280B in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF280B-to-partner and partner-to-ZNF280B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by ZNF280B-low versus ZNF280B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF280B→partner) and Y-score (partner→ZNF280B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.306	+1.247	.011	.045	3	2
UCEC	FoxM1 →	+0.178	+1.247	.043	.045	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.407	-2.124	.007	.001	3	2
UCEC	ASNS →	+0.413	+3.700	<.001	.001	3	2
UCEC	4E-BP1_pT37_T46 →	-0.273	-1.687	.032	.040	3	2
UCEC	EGFR_pY1068 →	-0.224	-1.906	.008	.015	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

eEF2 by ZNF280B expression — UCEC

Explore this box plot interactively →