ZNF280B

Across TCGA cell cohorts, ZNF280B mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible ZNF280B-associated genes across cancer lineages are GZMK, ARGFX, and TBC1D3H. Each is linked with ZNF280B in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF280B-to-partner and partner-to-ZNF280B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GZMK grouped by ZNF280B-low versus ZNF280B-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF280B→partner) and Y-score (partner→ZNF280B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	GZMK →	+0.034	+5.196	<.001	.005	3	1
OVARY	ARGFX →	+0.049	+5.196	<.001	.005	3	1
OVARY	TBC1D3H →	+0.514	+5.196	<.001	.005	3	1
LUNG_NSCLC_LUAD	TBATA →	+0.158	+3.959	<.001	.001	3	1
LUNG_NSCLC_LUAD	OR8B4 →	+0.027	+3.887	<.001	.002	3	1
LARGE_INTESTINE	SERPINB12 →	+0.143	+3.823	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

GZMK by ZNF280B expression — OVARY

Explore this box plot interactively →