ZNF268

Across TCGA cell cohorts, ZNF268 mutation is significantly associated with the RNA expression of many other genes, with 151 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZNF268-associated genes across cancer lineages are KRTAP5-5, OR4F6, and FABP12. Each is linked with ZNF268 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF268-to-partner and partner-to-ZNF268 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP5-5 grouped by ZNF268-low versus ZNF268-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF268→partner) and Y-score (partner→ZNF268) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	KRTAP5-5 →	+0.014	+4.437	<.001	.004	3	2
BLOOD_Leukemia	OR4F6 →	+0.028	+4.922	<.001	.009	3	1
BLOOD_Leukemia	FABP12 →	+0.081	+5.201	<.001	.006	3	1
BLOOD_Leukemia	OR10G4 →	+0.035	+4.922	<.001	.009	3	1
LUNG_NSCLC_LUAD	TNN →	+0.130	+3.760	<.001	.008	3	1
LARGE_INTESTINE	CBY1 →	+0.539	+3.299	.008	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 151 associations by consensus.

KRTAP5-5 by ZNF268 expression — SKIN

Explore this box plot interactively →