ZNF266

Across TCGA cell cohorts, ZNF266 mutation is significantly associated with the RNA expression of many other genes, with 37 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZNF266-associated genes across cancer lineages are VWC2L, KHDC3L, and RBMY1J. Each is linked with ZNF266 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF266-to-partner and partner-to-ZNF266 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VWC2L grouped by ZNF266-low versus ZNF266-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF266→partner) and Y-score (partner→ZNF266) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	VWC2L →	+0.012	+3.103	<.001	.004	3	2
SKIN	KHDC3L →	+0.019	+3.217	<.001	.006	3	2
SKIN	RBMY1J →	+0.004	+3.562	<.001	.002	3	2
LUNG_SCLC	OR1D5 →	+0.033	+5.643	<.001	.002	3	1
BLOOD_Lymphoma	CRYGD →	+0.036	+5.209	.003	.005	3	1
SKIN	PAK5 →	+0.071	+3.921	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

VWC2L by ZNF266 expression — SKIN

Explore this box plot interactively →