ZNF260

Across TCGA patient cohorts, ZNF260 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF260-associated genes across cancer lineages are EGFR, eIF4E, and eIF4G. Each is linked with ZNF260 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF260-to-partner and partner-to-ZNF260 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR grouped by ZNF260-low versus ZNF260-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF260→partner) and Y-score (partner→ZNF260) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR →	-0.199	-2.115	<.001	.017	3	1
UCEC	eIF4E →	+0.193	+2.807	.010	.003	3	1
UCEC	eIF4G →	+0.240	+2.999	.032	.035	3	1
UCEC	A-Raf_pS299 →	-0.096	-2.321	.025	.033	3	1
UCEC	ERK2 →	+0.174	+1.700	.012	.042	3	1
UCEC	FoxM1 →	+0.212	+1.584	.023	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

EGFR by ZNF260 expression — UCEC

Explore this box plot interactively →