ZNF260

Across TCGA pan-cancer cohorts, ZNF260 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of ZNF260’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where ZNF260 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ZNF260 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

BLCA, LUAD, and LIHC are the cancer types where ZNF260 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZNF260 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	All	All	+0.926	<.001	10	view →
LUAD	Male	II,III,IV	+1.018	<.001	9	view →
LIHC	Female	II,III,IV	+1.135	<.001	8	view →
BRCA	All	II,III,IV	+0.610	<.001	8	view →
THCA	All	II,III,IV	−0.460	<.001	8	view →
KICH	All	All	−0.620	<.001	7	view →
LUSC	Female	All	+0.846	<.001	6	view →
HNSC	All	All	+0.356	.016	6	view →
CHOL	Male	All	+2.250	<.001	5	view →
STAD	All	II,III,IV	+0.562	.013	4	view →
KIRP	All	IV	+0.719	.026	2	view →
READ	All	III,IV	+0.575	.017	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

ZNF260–BLCA

Open the BLCA breakdown →