Across TCGA patient cohorts, ZNF257 mutation is significantly associated with the RNA expression of many other genes, with 3,535 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF257-associated genes across cancer lineages are RNU6-642P, KLHL23, and OR51A6P. Each is linked with ZNF257 in more than 3 cancer types. Because this analysis shows association rather than direction, both ZNF257-to-partner and partner-to-ZNF257 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF257→partner) and Y-score (partner→ZNF257) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIRC	RNU6-642P →	+0.325	+4.988	<.001	.009	3	4
LUAD	KLHL23 →	+0.513	+3.369	.003	.004	3	4
KIRC	OR51A6P →	+0.169	+5.377	<.001	.005	3	3
KIRC	OR5H15 →	+0.132	+6.540	<.001	.001	3	3
KIRC	LINC02855 →	+0.141	+4.988	.009	.009	3	3
UCEC	DBF4B →	+0.388	+1.901	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,535 associations by consensus.

Exploration

ZNF257 survival (RNA) · tumor vs normal (RNA) · all ZNF257 data types