ZNF256

Across TCGA patient cohorts, ZNF256 mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF256-associated genes across cancer lineages are MEK1, mTOR_pS2448, and PCNA. Each is linked with ZNF256 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF256-to-partner and partner-to-ZNF256 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by ZNF256-low versus ZNF256-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF256→partner) and Y-score (partner→ZNF256) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.502	+3.700	<.001	.001	3	2
UCEC	mTOR_pS2448 →	-0.179	-1.906	.002	.016	3	2
UCEC	PCNA →	+0.294	+2.415	<.001	.003	3	2
UCEC	TFRC →	+0.649	+3.459	.002	.005	3	2
UCEC	c-Met_pY1235 →	+0.066	+1.906	.026	.016	3	2
UCEC	Di-Ras3 →	-0.123	-1.906	.040	.016	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

MEK1 by ZNF256 expression — UCEC

Explore this box plot interactively →