ZNF256

Across TCGA pan-cancer cohorts, ZNF256 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of ZNF256’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where ZNF256 RNA is repressed in tumor relative to normal tissue. In most cancer types ZNF256 is over-expressed in tumor, although a few such as COAD and THCA show the opposite, repressed pattern.

COAD, THCA, and READ are the cancer types where ZNF256 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZNF256 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	II,III,IV	−0.725	<.001	8	view →
THCA	All	II,III,IV	−0.444	<.001	8	view →
READ	All	II,III,IV	−0.899	.010	6	view →
CHOL	All	All	+1.566	<.001	5	view →
LIHC	Female	All	+0.844	<.001	5	view →
LUSC	Male	All	+0.653	<.001	4	view →
UCEC	All	All	−0.479	.043	2	view →
ESCA	Female	All	−1.200	.008	1	view →
STAD	All	IV	+0.970	.040	1	view →
HNSC	Female	IV	−0.844	.049	1	view →
KIRC	All	All	+0.179	.026	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

ZNF256–COAD

Open the COAD breakdown →