ZNF256

Across TCGA cell cohorts, ZNF256 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible ZNF256-associated genes across cancer lineages are MMP26, ACSM6, and PRAMEF20. Each is linked with ZNF256 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF256-to-partner and partner-to-ZNF256 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MMP26 grouped by ZNF256-low versus ZNF256-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF256→partner) and Y-score (partner→ZNF256) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	MMP26 →	+0.026	+4.807	<.001	.006	3	1
LARGE_INTESTINE	ACSM6 →	+0.027	+4.169	<.001	.007	3	1
LARGE_INTESTINE	PRAMEF20 →	+0.012	+4.437	<.001	.004	3	1
LARGE_INTESTINE	CFHR2 →	+0.046	+4.437	<.001	.004	3	1
LUNG_NSCLC_LUAD	PRAMEF12 →	+0.071	+4.371	<.001	.005	3	1
LUNG_NSCLC_LUAD	TGIF2LY →	+0.404	+4.662	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

MMP26 by ZNF256 expression — BLOOD_Myeloma

Explore this box plot interactively →