ZNF253

Across TCGA patient cohorts, ZNF253 mutation is significantly associated with the RNA expression of many other genes, with 2,764 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF253-associated genes across cancer lineages are RPL35AP3, CHAF1B, and BTG3-AS1. Each is linked with ZNF253 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF253-to-partner and partner-to-ZNF253 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPL35AP3 grouped by ZNF253-low versus ZNF253-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF253→partner) and Y-score (partner→ZNF253) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RPL35AP3 →	+0.179	+2.323	.002	<.001	3	3
UCEC	CHAF1B →	+0.680	+2.392	<.001	<.001	3	3
SKCM	BTG3-AS1 →	+0.462	+3.504	.001	.002	3	2
READ	YWHAQP1 →	+0.139	+6.257	<.001	.001	3	2
CESC	RN7SKP258 →	+0.191	+5.144	<.001	.003	3	2
CESC	NAGPA-AS1 →	+0.182	+4.551	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,764 associations by consensus.

RPL35AP3 by ZNF253 expression — UCEC

Explore this box plot interactively →