ZNF253

Across TCGA pan-cancer cohorts, ZNF253 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of ZNF253’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where ZNF253 RNA is repressed in tumor relative to normal tissue. In most cancer types ZNF253 is over-expressed in tumor, although a few such as THCA and HNSC show the opposite, repressed pattern.

THCA, BLCA, and LIHC are the cancer types where ZNF253 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZNF253 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	II,III,IV	−1.034	<.001	9	view →
BLCA	Male	All	+1.153	<.001	7	view →
LIHC	Male	All	+0.846	<.001	6	view →
STAD	All	II,III,IV	+0.603	.002	6	view →
BRCA	All	II,III,IV	+0.394	<.001	6	view →
HNSC	All	II,III,IV	−0.455	.008	4	view →
CHOL	All	All	+1.342	<.001	3	view →
LUAD	All	All	+0.467	<.001	3	view →
ESCA	All	II,III,IV	+1.649	.048	2	view →
PRAD	All	All	+0.532	<.001	2	view →
KIRP	Male	All	−0.331	.046	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

ZNF253–THCA

Open the THCA breakdown →