ZNF253

Across TCGA patient cohorts, ZNF253 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF253-associated genes across cancer lineages are mTOR_pS2448, Notch1, and PKC-delta_pS664. Each is linked with ZNF253 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF253-to-partner and partner-to-ZNF253 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by ZNF253-low versus ZNF253-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF253→partner) and Y-score (partner→ZNF253) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.140	-1.680	.014	.042	3	2
UCEC	Notch1 →	+0.233	+2.087	<.001	.005	3	2
UCEC	PKC-delta_pS664 →	-0.094	-2.000	.041	.029	3	2
UCEC	14-3-3_beta →	-0.125	-3.673	.001	.001	3	1
UCEC	EGFR_pY1068 →	-0.313	-2.906	.001	.001	3	1
UCEC	A-Raf_pS299 →	-0.181	-3.906	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

mTOR_pS2448 by ZNF253 expression — UCEC

Explore this box plot interactively →