ZNF253

Across TCGA cell cohorts, ZNF253 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,524 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible ZNF253-associated GO terms across cancer lineages are Positive regulation of double-strand break repair, Regulation of nucleotide-excision repair, and Regulation of heterochromatin formation. Each is linked with ZNF253 in more than 10 cancer types. Because this analysis shows association rather than direction, both ZNF253-to-partner and partner-to-ZNF253 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of double-strand break repair grouped by ZNF253-low versus ZNF253-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF253→partner) and Y-score (partner→ZNF253) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Positive regulation of double-strand break repair →	+0.077	+1.261	<.001	<.001	3	11
BREAST	Regulation of nucleotide-excision repair →	+0.107	+0.976	<.001	.002	3	11
LUNG_SCLC	Regulation of heterochromatin formation →	+0.158	+1.600	<.001	<.001	3	10
SOFT_TISSUE	Regulation of double-strand break repair →	+0.076	+1.307	<.001	<.001	3	10
SOFT_TISSUE	Regulation of double-strand break repair via homologous recombination →	+0.100	+1.458	<.001	<.001	3	9
BLOOD_Leukemia	Regulation of cytoplasmic mRNA processing body assembly →	+0.107	+0.961	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,524 associations by consensus.

Positive regulation of double-strand break repair by ZNF253 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →