ZNF253

Across TCGA cell cohorts, ZNF253 mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZNF253-associated genes across cancer lineages are RNASE8, TBC1D3C, and OR2M4. Each is linked with ZNF253 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF253-to-partner and partner-to-ZNF253 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNASE8 grouped by ZNF253-low versus ZNF253-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF253→partner) and Y-score (partner→ZNF253) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	RNASE8 →	+0.050	+3.475	<.001	.006	3	1
BLOOD_Leukemia	TBC1D3C →	+1.079	+3.605	.001	.007	2	2
OVARY	OR2M4 →	+0.076	+4.700	<.001	.002	3	1
OVARY	OR11H2 →	+0.046	+4.450	.002	.004	3	1
OVARY	OR13C2 →	+0.046	+4.228	.009	.006	3	1
CNS	IL21 →	+0.038	+4.981	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

RNASE8 by ZNF253 expression — BLOOD_Leukemia

Explore this box plot interactively →