ZNF24

Across TCGA patient cohorts, ZNF24 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF24-associated genes across cancer lineages are GSK-3a-b_pS21_S9, Annexin-1, and Tuberin_pT1462. Each is linked with ZNF24 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF24-to-partner and partner-to-ZNF24 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GSK-3a-b_pS21_S9 grouped by ZNF24-low versus ZNF24-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF24→partner) and Y-score (partner→ZNF24) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GSK-3a-b_pS21_S9 →	+0.486	+2.331	.018	.019	3	1
UCEC	Annexin-1 →	+0.610	+3.019	.016	.019	3	1
UCEC	Tuberin_pT1462 →	+0.381	+2.469	<.001	.010	3	1
UCEC	Tuberin →	+0.429	+3.584	<.001	.002	3	1
UCEC	VHL →	-0.782	-2.321	.017	.034	3	1
UCEC	Bcl-xL →	-0.168	-2.459	.030	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

GSK-3a-b_pS21_S9 by ZNF24 expression — UCEC

Explore this box plot interactively →