ZNF24

Across TCGA pan-cancer cohorts, ZNF24 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated ZNF24 data layer compared with 5 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher ZNF24 RNA is associated with better overall survival. In most high-consensus cancer types, elevated ZNF24 expression acts as an unfavorable survival marker, although some lineages such as KIRC and HNSC show a favorable association.

KIRC, UVM, and HNSC are the cancer types where ZNF24 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.711	0.558	<.001	85	view →
UVM	DFS	Median	III,IV	0.267	0.796	.002	43	view →
HNSC	DFS	Tertile	IV	0.744	0.537	<.001	42	view →
ACC	DFS	Quartile	All	0.198	0.834	<.001	29	view →
THYM	DFS	Tertile	All	1.000	0.630	.006	21	view →
GBM	DFS	Median	All	0.404	0.174	<.001	18	view →
MESO	DFS	Median	IV	0.173	0.454	.009	15	view →
CHOL	DFS	Median	All	0.726	0.227	.019	12	view →
LUAD	OS	Quartile	III,IV	0.754	0.542	.023	11	view →
SCLC	DFS	Tertile	IV	0.155	0.776	.022	9	view →
PAAD	DFS	Quartile	All	0.398	0.160	.023	9	view →
LGG	OS	Median	All	0.765	0.897	.007	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

ZNF24–KIRC (OS)

Open the KIRC breakdown →