ZNF235

Across TCGA patient cohorts, ZNF235 mutation is significantly associated with the RNA expression of many other genes, with 2,612 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF235-associated genes across cancer lineages are ORC5, BUB1, and L2HGDH. Each is linked with ZNF235 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF235-to-partner and partner-to-ZNF235 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ORC5 grouped by ZNF235-low versus ZNF235-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF235→partner) and Y-score (partner→ZNF235) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ORC5 →	+0.382	+2.115	<.001	<.001	3	3
UCEC	BUB1 →	+0.533	+1.923	.008	.009	3	3
UCEC	L2HGDH →	+0.439	+2.103	.001	.003	3	3
UCEC	LAG3 →	+0.867	+4.098	<.001	<.001	3	3
SKCM	RPF1 →	+0.538	+3.522	.003	.002	3	3
SKCM	TYW3 →	+0.572	+2.353	.006	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,612 associations by consensus.

ORC5 by ZNF235 expression — UCEC

Explore this box plot interactively →