ZNF235

Across TCGA pan-cancer cohorts, ZNF235 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated ZNF235 data layer compared with 5 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ZNF235 RNA is associated with better overall survival. In most high-consensus cancer types, elevated ZNF235 expression acts as an unfavorable survival marker, although some lineages such as HNSC and KIRC show a favorable association.

HNSC, KIRC, and LGG are the cancer types where ZNF235 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Quartile	All	0.821	0.626	.001	79	view →
KIRC	OS	Tertile	All	0.924	0.829	<.001	78	view →
LGG	DFS	Median	All	0.660	0.825	<.001	53	view →
PAAD	OS	Quartile	II,III,IV	0.692	0.410	.008	46	view →
LUSC	DFS	Quartile	III,IV	0.549	0.851	.001	31	view →
LIHC	DFS	Tertile	All	0.442	0.603	.001	22	view →
SARC	DFS	Tertile	All	0.667	0.382	<.001	21	view →
GBM	DFS	Quartile	All	0.427	0.160	.002	17	view →
ESCA	DFS	Tertile	IV	0.704	0.252	.024	15	view →
CHOL	OS	Tertile	All	1.000	0.245	.037	12	view →
READ	OS	Quartile	II,III,IV	0.962	0.305	.004	12	view →
MESO	DFS	Quartile	III,IV	0.166	0.732	.010	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

ZNF235–HNSC (OS)

Open the HNSC breakdown →