ZNF235

Across TCGA patient cohorts, ZNF235 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF235-associated genes across cancer lineages are Tuberin_pT1462, ERCC1, and IRS1. Each is linked with ZNF235 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF235-to-partner and partner-to-ZNF235 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Tuberin_pT1462 grouped by ZNF235-low versus ZNF235-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF235→partner) and Y-score (partner→ZNF235) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Tuberin_pT1462 →	+0.265	+3.000	.049	.035	3	2
UCEC	ERCC1 →	-0.160	-2.502	.006	.001	3	2
UCEC	IRS1 →	+0.151	+1.514	.033	.015	3	2
UCEC	MEK1 →	+0.350	+1.807	.005	.004	3	2
UCEC	Notch1 →	+0.136	+1.514	.004	.015	3	2
UCEC	PCNA →	+0.184	+2.321	.012	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

Tuberin_pT1462 by ZNF235 expression — SKCM

Explore this box plot interactively →