ZNF235

Across TCGA cell cohorts, ZNF235 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZNF235-associated genes across cancer lineages are PRAC1, GJD2, and C1QB. Each is linked with ZNF235 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF235-to-partner and partner-to-ZNF235 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRAC1 grouped by ZNF235-low versus ZNF235-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF235→partner) and Y-score (partner→ZNF235) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PRAC1 →	+2.879	+3.556	.002	.007	3	1
LARGE_INTESTINE	GJD2 →	+0.002	+3.700	<.001	.009	3	1
LARGE_INTESTINE	C1QB →	+0.092	+2.994	<.001	.006	3	1
LARGE_INTESTINE	OR10Q1 →	+0.082	+3.242	.005	.003	3	1
BLOOD_Leukemia	SOX14 →	+0.003	+3.269	<.001	.007	3	1
BLOOD_Leukemia	DNER →	+0.098	+3.345	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

PRAC1 by ZNF235 expression — LARGE_INTESTINE

Explore this box plot interactively →