ZNF232

Across TCGA patient cohorts, ZNF232 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF232-associated genes across cancer lineages are eIF4E, ATM, and EGFR_pY1068. Each is linked with ZNF232 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF232-to-partner and partner-to-ZNF232 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by ZNF232-low versus ZNF232-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF232→partner) and Y-score (partner→ZNF232) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.178	+3.013	.036	.018	3	2
UCEC	ATM →	-0.497	-3.156	.006	.018	3	2
UCEC	EGFR_pY1068 →	-0.200	-1.906	.047	.016	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.569	+1.906	.005	.016	3	1
UCEC	MEK1 →	+0.412	+2.700	.005	.006	3	1
UCEC	MSH2 →	-0.221	-2.990	.017	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

eIF4E by ZNF232 expression — UCEC

Explore this box plot interactively →