ZNF229

Across TCGA patient cohorts, ZNF229 mutation is significantly associated with the RNA expression of many other genes, with 4,476 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF229-associated genes across cancer lineages are SEC24D, PANK4, and GPATCH3. Each is linked with ZNF229 in more than 3 cancer types. Because this analysis shows association rather than direction, both ZNF229-to-partner and partner-to-ZNF229 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SEC24D grouped by ZNF229-low versus ZNF229-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF229→partner) and Y-score (partner→ZNF229) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	SEC24D →	+0.591	+3.831	.001	<.001	3	4
COAD	PANK4 →	+0.423	+3.223	.002	.009	3	4
SKCM	GPATCH3 →	+0.219	+2.051	.005	.001	3	4
UCEC	RNU6-718P →	+0.084	+2.555	.002	.003	3	4
UCEC	C12orf43 →	+0.234	+1.776	<.001	<.001	3	4
UCEC	RER1 →	+0.228	+4.491	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,476 associations by consensus.

SEC24D by ZNF229 expression — LUSC

Explore this box plot interactively →