ZNF229

Across TCGA pan-cancer cohorts, ZNF229 RNA differs between tumor and matched normal tissue in 17 of 18 cancer types tested, making tumor–normal expression one of ZNF229’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where ZNF229 RNA is repressed in tumor relative to normal tissue. In most cancer types ZNF229 is over-expressed in tumor, although a few such as KIRC and COAD show the opposite, repressed pattern.

KIRC, COAD, and HNSC are the cancer types where ZNF229 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZNF229 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	−0.663	<.001	11	view →
COAD	All	IV	−0.684	<.001	10	view →
HNSC	Female	IV	−0.836	<.001	9	view →
LUAD	Male	II,III,IV	+1.360	<.001	8	view →
THCA	Male	All	−0.750	<.001	8	view →
KICH	All	All	−0.758	<.001	7	view →
UCEC	All	III,IV	−1.929	<.001	6	view →
CHOL	Male	All	+1.616	<.001	5	view →
LUSC	All	All	+0.656	<.001	5	view →
BRCA	All	All	−0.398	.001	4	view →
READ	All	All	−0.915	<.001	3	view →
LIHC	All	All	+0.380	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 17 lineages.

ZNF229–KIRC

Open the KIRC breakdown →