ZNF229

Across TCGA patient cohorts, ZNF229 mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF229-associated genes across cancer lineages are EGFR_pY1068, HER2, and STAT3_pY705. Each is linked with ZNF229 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF229-to-partner and partner-to-ZNF229 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by ZNF229-low versus ZNF229-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF229→partner) and Y-score (partner→ZNF229) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	EGFR_pY1068 →	-0.121	-1.857	.012	.047	3	2
SKCM	HER2 →	+0.216	+1.874	.010	.047	3	2
UCEC	STAT3_pY705 →	-0.340	-1.925	<.001	.004	3	2
UCEC	PCNA →	+0.162	+1.362	.012	.034	3	2
UCEC	Tuberin_pT1462 →	+0.204	+1.440	.003	.020	3	2
UCEC	4E-BP1 →	+0.302	+2.584	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

EGFR_pY1068 by ZNF229 expression — SKCM

Explore this box plot interactively →