ZNF229

Across TCGA cell cohorts, ZNF229 mutation is significantly associated with the RNA expression of many other genes, with 26 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ZNF229-associated genes across cancer lineages are OR11H2, LYZL1, and MAGEB5. Each is linked with ZNF229 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF229-to-partner and partner-to-ZNF229 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR11H2 grouped by ZNF229-low versus ZNF229-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF229→partner) and Y-score (partner→ZNF229) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	OR11H2 →	+0.034	+4.201	<.001	.001	3	2
LUNG_NSCLC_LUSC	LYZL1 →	+0.026	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	MAGEB5 →	+0.033	+4.643	<.001	.008	3	1
OVARY	PRR27 →	+0.074	+3.444	<.001	.003	3	1
OVARY	DAZ1 →	+0.102	+4.058	<.001	.001	3	1
OVARY	DEFA1 →	+0.376	+3.624	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

OR11H2 by ZNF229 expression — BLOOD_Leukemia

Explore this box plot interactively →