ZNF227

Across TCGA patient cohorts, ZNF227 mutation is significantly associated with the RNA expression of many other genes, with 1,380 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF227-associated genes across cancer lineages are SLC25A51P3, KRTAP15-1, and SAMD11. Each is linked with ZNF227 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF227-to-partner and partner-to-ZNF227 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC25A51P3 grouped by ZNF227-low versus ZNF227-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF227→partner) and Y-score (partner→ZNF227) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SLC25A51P3 →	+0.103	+1.969	<.001	.008	3	2
COAD	KRTAP15-1 →	+0.119	+4.087	<.001	.006	3	2
COAD	SAMD11 →	-0.720	-3.432	.002	.005	3	2
COAD	ASB13 →	-0.610	-3.405	<.001	.005	3	2
COAD	RNU6-666P →	+0.429	+4.412	<.001	.004	3	2
UCEC	CD27-AS1 →	-0.700	-2.662	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,380 associations by consensus.

SLC25A51P3 by ZNF227 expression — UCEC

Explore this box plot interactively →