ZNF226

Across TCGA patient cohorts, ZNF226 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF226-associated genes across cancer lineages are ATM, A-Raf_pS299, and Ku80. Each is linked with ZNF226 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF226-to-partner and partner-to-ZNF226 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by ZNF226-low versus ZNF226-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF226→partner) and Y-score (partner→ZNF226) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.696	-2.392	<.001	<.001	3	3
SKCM	A-Raf_pS299 →	-0.235	-3.000	.004	.036	3	2
UCEC	Ku80 →	+0.243	+2.013	.003	.001	3	2
UCEC	MEK1 →	+0.387	+3.000	.002	<.001	3	2
UCEC	PCNA →	+0.231	+2.000	.002	.003	3	2
UCEC	4E-BP1 →	+0.285	+2.459	.002	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

ATM by ZNF226 expression — UCEC

Explore this box plot interactively →