ZNF226

Across TCGA cell cohorts, ZNF226 mutation is significantly associated with the RNA expression of many other genes, with 34 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZNF226-associated genes across cancer lineages are CLPS, ZIM3, and TBL1Y. Each is linked with ZNF226 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF226-to-partner and partner-to-ZNF226 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CLPS grouped by ZNF226-low versus ZNF226-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF226→partner) and Y-score (partner→ZNF226) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	CLPS →	+0.083	+5.169	<.001	<.001	3	2
PANCREAS	ZIM3 →	+0.005	+4.614	<.001	.004	3	1
PANCREAS	TBL1Y →	+0.005	+4.614	<.001	.004	3	1
LARGE_INTESTINE	AVP →	+0.038	+3.217	<.001	.006	3	1
LARGE_INTESTINE	MAGEB4 →	+0.014	+4.000	<.001	<.001	3	1
LARGE_INTESTINE	SEPTIN14 →	+0.007	+3.514	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

CLPS by ZNF226 expression — LUNG_SCLC

Explore this box plot interactively →