ZNF225

Across TCGA cell cohorts, ZNF225 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZNF225-associated genes across cancer lineages are CSN2, IL36RN, and PSG6. Each is linked with ZNF225 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF225-to-partner and partner-to-ZNF225 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CSN2 grouped by ZNF225-low versus ZNF225-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF225→partner) and Y-score (partner→ZNF225) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	CSN2 →	+0.042	+3.817	<.001	.004	3	1
LUNG_SCLC	IL36RN →	+0.186	+3.887	<.001	.005	3	1
LUNG_SCLC	PSG6 →	+0.063	+3.523	<.001	.008	3	1
LUNG_SCLC	PLET1 →	+0.037	+3.807	<.001	.006	3	1
LUNG_SCLC	POTEB →	+0.008	+4.058	<.001	.007	3	1
BLOOD_Leukemia	OR52E2 →	+0.010	+3.969	.006	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

CSN2 by ZNF225 expression — LUNG_SCLC

Explore this box plot interactively →