ZNF224

Across TCGA patient cohorts, ZNF224 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF224-associated genes across cancer lineages are eIF4E, mTOR_pS2448, and Notch1. Each is linked with ZNF224 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF224-to-partner and partner-to-ZNF224 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by ZNF224-low versus ZNF224-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF224→partner) and Y-score (partner→ZNF224) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.238	+3.713	.001	<.001	3	2
UCEC	mTOR_pS2448 →	-0.195	-3.794	<.001	<.001	3	2
UCEC	Notch1 →	+0.222	+2.321	<.001	.001	3	2
UCEC	PCNA →	+0.329	+2.807	<.001	<.001	2	3
UCEC	PKC-delta_pS664 →	-0.090	-2.584	.036	.010	3	2
UCEC	PREX1 →	-0.243	-1.700	.014	.040	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

eIF4E by ZNF224 expression — UCEC

Explore this box plot interactively →