ZNF22-AS1

Across TCGA pan-cancer cohorts, ZNF22-AS1 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated ZNF22-AS1 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher ZNF22-AS1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated ZNF22-AS1 expression acts as an unfavorable survival marker, although some lineages such as KIRC and UCS show a favorable association.

KIRC, UCS, and STAD are the cancer types where ZNF22-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.888	0.703	<.001	83	view →
UCS	DFS	Quartile	II,III,IV	0.625	0.140	.002	62	view →
STAD	DFS	Quartile	All	0.329	0.571	.006	49	view →
LIHC	OS	Median	All	0.642	0.886	<.001	43	view →
BLCA	OS	Quartile	II,III,IV	0.342	0.594	.017	33	view →
MESO	DFS	Tertile	All	0.268	0.464	.005	21	view →
UCEC	DFS	Median	IV	0.648	0.303	.029	18	view →
DLBC	DFS	Quartile	II,III,IV	0.128	1.000	.001	17	view →
CHOL	OS	Tertile	All	0.868	0.284	.008	15	view →
LUSC	DFS	Median	II,III,IV	0.309	0.490	.004	13	view →
SCLC	DFS	Quartile	II,III,IV	0.968	0.338	.024	13	view →
OV	DFS	Quartile	IV	0.642	0.348	.007	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

ZNF22-AS1–KIRC (DFS)

Open the KIRC breakdown →