ZNF22-AS1

Across TCGA pan-cancer cohorts, ZNF22-AS1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of ZNF22-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where ZNF22-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ZNF22-AS1 is over-expressed in tumor, although a few such as THCA and LUAD show the opposite, repressed pattern.

KIRC, HNSC, and THCA are the cancer types where ZNF22-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZNF22-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	+0.827	<.001	11	view →
HNSC	Female	All	+0.572	<.001	11	view →
THCA	All	II,III,IV	−0.353	<.001	10	view →
LUAD	Female	III,IV	−1.323	<.001	9	view →
LUSC	Female	II,III,IV	−1.321	<.001	9	view →
KICH	All	All	−0.845	<.001	7	view →
UCEC	All	All	−0.997	<.001	6	view →
BRCA	All	II,III,IV	−0.443	<.001	6	view →
STAD	All	All	+0.418	.007	5	view →
BLCA	Male	IV	−1.090	.015	2	view →
CHOL	All	All	+0.507	.013	2	view →
COAD	All	IV	−0.387	.038	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

ZNF22-AS1–KIRC

Open the KIRC breakdown →