ZNF217

Across TCGA patient cohorts, ZNF217 mutation is significantly associated with the total protein of many other genes, with 63 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF217-associated genes across cancer lineages are Caspase-7-cleavedD198, C-Raf, and PDK1_pS241. Each is linked with ZNF217 in more than 3 cancer types. Because this analysis shows association rather than direction, both ZNF217-to-partner and partner-to-ZNF217 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by ZNF217-low versus ZNF217-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF217→partner) and Y-score (partner→ZNF217) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.602	+1.945	.001	.002	3	4
UCEC	C-Raf →	+0.170	+2.000	<.001	<.001	3	3
LUAD	PDK1_pS241 →	-0.236	-3.153	.012	.019	3	2
LUAD	Caveolin-1 →	-0.773	-3.000	.040	.035	2	3
BRCA	STAT5a →	+0.528	+3.000	.027	.038	3	2
COAD	p21 →	+0.245	+2.212	.017	.033	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 63 associations by consensus.

Caspase-7-cleavedD198 by ZNF217 expression — UCEC

Explore this box plot interactively →